- Her Boston accent in Gone Baby Gone (2007) was so convincing that Ben Affleck, a Boston native, asked what part of the city she was from, and a security guard once initially refused to let her on set as he believed that she was a local fan.
- Director Sidney Lumet was so impressed with her ability that he cast her in three different roles -- Ellen, Paris and Rebecca -- in his television series Tribunal central (2001).
- Was nominated for Broadway's 2005 Tony Award as Best Actress (Featured Role - Play) for a revival of "A Streetcar Named Desire."
- Ryan, her professional surname, is her mother's maiden name.
- Best friends with Patricia Clarkson.
- Gave birth to her 1st child at age 41, a daughter Georgia Gracie Slovin on October 15, 2009. Child's father is her fiance [now husband], Eric Slovin.
- Graduated from New York City's High School of Performing Arts.
- Was nominated for Broadway's 2000 Tony Award as Best Actress (Featured Role - Play) for a revival of "Uncle Vanya."
- As of 2016, has appeared in 3 films that were nominated for the Best Picture Oscar: Truman Capote (2005), Birdman ou (La Surprenante vertu de l'ignorance) (2014) and Le Pont des espions (2015). Of those, Birdman is a winner in the category.
- Appeared with Philip Seymour Hoffman in 3 films: Truman Capote (2005), 7h58 ce samedi-là (2007) and Rendez-vous l'été prochain (2010).
- She is of English, Irish, and Polish descent.
- Was 3 months pregnant with her daughter Georgia when she completed filming Rendez-vous l'été prochain (2010).
- Returned to work 5 months after giving birth to her daughter Georgia to begin filming Les Winners (2011).
- Her first film role was in Allison Anders' 1996 film Grace of My Heart (1996), although her scene was later cut. She played the second wife of Eric Stoltz's character, in a scene where he picks up his daughter from first wife Illeana Douglas' apartment.
- Attended Stagedoor Manor Performing Arts Training Center.
- First appeared on Broadway in "The Sisters Rosensweig".
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