Alphas was originally called "Section 8, Alphas" during development. Although initially developed in 2006, it wasn't until 2009 that it was picked up by a network.
With the appearance of Lindsay Wagner as Dr. Vanessa Calder in the episode "Never Let Me Go", ALPHAS is tied into the same "universe" as "Warehouse 13" and "Eureka".
Season 2 episode 12 the character Zoe (Skylar Wexler) asks Skylar Adams (Summer Glau) if a tracking device was a terminator. This is a homage to Summer Glau playing the part of Cameron Phillips and Allison Young in the Fox series Terminator: The Sarah Connor Chronicles (2008).
Co-stars Warren Christie & Laura Mennell would co-star once again together in another TV series called, "Motive (2014)
Callum Keith Rennie played Ray McDere on the tv show version of The Firm, and David Stathairn played the same character in the film version of The Firm.