In late 1996, Nyro, like her mother before her, was diagnosed with ovarian cancer. After the diagnosis, Columbia Records prepared a double-disc CD retrospective of material from her years at the label. The company involved Nyro herself, who selected the tracks and approved the final project. She lived to see the release of Stoned Soul Picnic: The Best of Laura Nyro (1997), and was reportedly pleased with the outcome. She died of ovarian cancer in Danbury, Connecticut, on April 8, 1997, at 49, the same age at which the disease had claimed the life of her mother. Her ashes were buried beneath a maple tree on the grounds of her house in Danbury.