Sean Hayes, Eric McCormack, Debra Messing, and Megan Mullally in Will & Grace (1998)

Eric McCormack and Debra Messing in Will & Grace (1998)

Woody Allen, Téa Leoni, and Debra Messing in Hollywood Ending (2002)

Woody Allen and Debra Messing in Hollywood Ending (2002)

Judy Davis, Debra Messing, Reuben Jackson, and Michael Lerner in Celebrity (1998)

Alyssa Milano, Debra Messing, Isaac Mizrahi, and Georgina Chapman in Project Runway All Stars (2012)

Alyssa Milano and Debra Messing in Project Runway All Stars (2012)

Debra Messing and John Cho in Searching (2018)

Debra Messing and Steven Michael Eich in Searching (2018)

Ric Sarabia, Debra Messing, and John Cho in Searching (2018)

Debra Messing and Ben Cain in Searching (2018)

Natasha Lyonne, Debra Messing, and Megan Mullally in Will & Grace (1998)

Debra Messing and Ellen Pompeo in Debra Messing & Ellen Pompeo (2025)

Heather Locklear, Dermot Mulroney, Debra Messing, Hilary Duff, Chris Noth, and Aria Wallace in The Wedding Date (2005)