Biggest Movie Losers

These are movie characters who are perpetual losers, because their life, their circumstances or simply their environment is keeping them down. But they fight and some of them don't give up aiming for a normal condition. Which of these struggling, losing characters below is the most interesting to you?

(The loser has to be from movies rated minimum 6.5/10 stars on IMDb. No animation allowed but characters can be either from real life or fictional. One exception: When the loser is so significant that he's worth standing next to the other losers below, the movie can be rated down to 5.5/10.)

Discuss here.

A special thank you to Dan Dassow, Jen & Djesika, who helped me so much correcting my typos.