Denzel Washington was actually waterboarded during the filming of some of the torture scene, though only for a few seconds per take.
Thanks to a clause in the contract giving Denzel Washington director approval, Espinosa wasn't fired, despite artistic differences between him and the producers. Denzel said that he wanted Espinosa to direct, and that's that, so the producers let Espinosa finish the movie.
During the filming of the 'escape from the boot of the car' scene, performed with actual full-speed, unprotected driving by Reynolds, as he and Denzel wrestle for control of the car, Ryan's head smashed into Denzel, giving him a lump over his right eye. They reset for a new take, filming from the other side so as to hide the injury, and it happened again, giving D.W. matching forehead lumps. This necessitated a halt in production for a couple of days, during which, according to Reynolds, Denzel "resembled an old-fashioned Christmas ornament!"
Safe House is the most financially successful film ever by a Swedish director.
The movie was originally set in the favelas of Rio de Janeiro, but the production decided not to shoot there, due to security concerns.