Rocket's subject name '89P13' had previously appeared on his mugshot in Guardiani della Galassia (2014) along with his alias 'Rocket'
Lylla, Rocket's fellow test subject, was previously mentioned in Guardiani della Galassia (2014), as one of Rocket's known associates (only Lylla and Groot are named)
This film sets the record for the most makeup appliances used in a single film. The numbers are staggering, totaling 22,541 prosthetics, 500 wigs, and 117 pairs of contacts by the end, used across more than 1,000 actors.
Cosmo is female in this film, as a tribute to Laika the soviet dog, one of the first animals in space.
After James Gunn was fired as director, actor Dave Bautista (Drax) became one of Gunn's most vocal supporters, tweeting that "James Gunn is one of the most loving, caring, good natured people I have ever met. He's gentle and kind and cares deeply for people and animals. He's made mistakes. We all have. I'm NOT ok with what's happening to him." Bautista even stated that he would demand to be released from his contract if the studio did not use the screenplay Gunn had originally written for this film. Gunn was later re-hired.