Lista episodi

Inizia con la stessa sequenza di apertura della serie, tranne per il fatto che il Professore aggiunge accidentalmente una lattina di whoopass anziché Chemical X.

In «Monkey See, Doggie Do», Mojo Jojo ruba alcuni manufatti maledetti dal Museo di Townsville e usandoli trasforma tutta la gente di Townsville e poi il mondo intero in cani.

"Insect Inside" The city of Townsville becomes overrun by millions of cockroaches, led by their leader Roach Coach. The Powerpuff Girls must fight their fear of bugs in order to save the city.

"Octi-Evil" Him is out to break up the Powerpuff Girls, and uses Bubbles sweetness to do it via Bubbles' stuffed octopus, Octi. "Geshundfight" The amoeba boys try to commit a crime and accidentally get the whole city of Townsville sick.

"Buttercrush" Buttercup develops a crush on Ace, the leader of the Gang Green Gang. They soon take advantage of this to put Blossom and Bubbles into terrible danger.

In "Boogie Frights", the Boogie Man comes up with a plan to forever keep out light in order to operate freely, but the Powerpuff Girls are on the job in a jiffy. In "Abracadaver", a long-dead resident magician, Al Lusion, comes back to life as a zombie, and the girls have some difficulty in trying to stop him.

"Telephonies" The Gangreen Gang gets hold of the Powerpuff Girls Hotline and makes crank calls, sending the Girls on a wild goose chase trying to protect the town.

"Major Competition" The Powerpuff Girls' place as crime fighters is taken when Major Man comes to town. The PPGs eventually figure out that Major Man is actually faking disasters just so he can "save the day."

In "Paste Makes Waste", one of the Pokey Oaks Kindergarten students has a bad habit of eating glue and Buttercup just can't resist picking on him for this. But when he accidentally eats some radioactive glue and turns into a giant glue monster, it's up to Buttercup to apologize for her behavior toward him to reverse the process. In "Ice Sore", during an intense heat wave, Blossom develops a new superpower, one that makes her sisters jealous, but her schoolmates popular with her: ice breath.

Bubbles is tired of being the cute and wants to be "hard-core," but she takes it a little too far.

"Cat Man Do" The Girls save an innocent little Kitty from the clutches of an evil villain. Eventually they learn that Kitty is the true villain when he hypnotizes the Professor in an evil plot to take over the world.

In "Just Another Manic Mojo", Mojo Jojo's morning routine is disrupted by the Powerpuff Girls when their ball that they are playing with ends up in his lair. Mojo then uses this opportunity to try and eliminate his nemeses for good. In "Mime for a Change", Rainbow the Clown is accidentally transformed by bleach into an evil mime who can eliminate color and sound.

Mojo Jojo is so outraged at his constant defeats against the Powerpuff Girls that he decides to beat them at their own games, by creating The Rowdyruff Boys, who prove superior fighters to the girls.

Worried about his little girls' safety, the Professor creates Powerpuff Dynamo, a state-of-the-art protection system.