Andrea Martin, who played Phyllis in Black Christmas (Un Natale rosso sangue) (1974), said in an interview that she hadn't thought about "Black Christmas" for 32 years and it "came out of the blue" when Glen Morgan offered her the role as the house mother in the movie.
Glen Morgan approached Mary Elizabeth Winstead about the movie at 4 AM in the airport after finishing Final Destination 3 (2006) with her. After being hesitant at first after only just finishing a horror movie, she agreed to the role of "Heather" because she is a fan of the 1974 version.
After this film's critical and financial failure Bob Clark began work on a straight up sequel to the original film with Clark as director and Olivia Hussey and John Saxon reprising their roles of Jess Bradford and Lt. Ken Fuller, respectively, with Jess being the new house mother of the sorority house. His untimely passing however prevented this idea from ever coming to fruition.
All the girls did their own stunts.
During one scene the famous "leg lamp" from Una storia di Natale (1983) can be seen in the background. This may be a reference to Bob Clark, the director of the original Black Christmas. He also directed A Christmas Story in 1983.