The scene where Shah Rukh Khan walks into a lounge (as himself in the film) and meets Farhan Akhtar for the first time, he is shown to be accompanied by a man of his age. This guy is none other than Mushtaq Sheikh who is Shahrukh Khan's age old friend in real life and has written quite a few books on him apart from penning Om Shanti Om (2007) and also acting in it. In a way he is related to the plot. When Shah Rukh Khan tells Farhan Akhtar that he should not be forgetting his friends from the old times, a message is being conveyed because the superstar himself is shown to be in company of those (read Mushtaq) who have been with him through his good and bad times.
In one of the first scenes of the film, Aamir Khan is shown to be giving a shot for an imaginary Rajkumar Hirani film. This is a nod to the fact that the next venture of both Aamir and Rajkumar Hirani after Luck by Chance is together for the movie 3 Idiots (2009)
The writer/director Anurag Kashyap is playing a frustrated writer, in Luck By Chance. Someone who is ridiculed as an 'Institute' when he tries to write something that defies the Bollywood clichés. The producer also mocks him by saying that he doesn't want to make the movie for a film festival, which is a dig at Mr. Anurag Kashyap whose movies, which mostly get banned in India or struggle to get a good producer, work quite well at various prestigious film festivals (e.g. Black Friday (2004), Paanch (2003)). Anurag is shown as a writer who is forced to do DVD rip offs and not complain when changes are asked to be made, something that cleverly reflects on his career as writer so far.
Konkona Sen Sharma replaced Tabu in Zoya Akhtar's Luck By Chance. Tabu had some apprehensions about the story of the film. And she wanted to make some changes in it. Zoya, however, politely turned her request down and simply replaced Tabu with Konkona.
In his cameo, the actor Aamir Khan makes a spoof about himself. In one of the first scenes of the film, he is shown to be giving this 'perfect shot' for a Rajkumar Hirani film. All so intense and into the character, he returns back to the monitor, only to sound a little unhappy over the way he gave his shot. He and Raju acknowledge though that the subtle touch that he gave to the scene while adjusting his hat was quite thoughtful! All this was meant to be an exaggerated take on things.
Shah Rukh Khan, Aamir Khan: This film has a unique distinction of bringing together the actors in the same film, although their roles were very small, and they don't even share any scene together on screen but this has never happened before this movie and is very unlikely to happen too, given the busy schedules and the huge stardom of both the actors.