Aidan Delbis, who had never acted professionally before, was cast as Don after Yorgos Lanthimos decided to find a non-professional neurodivergent actor to provide a different dynamic alongside Emma Stone and Jesse Plemons.
Emma Stone had her head shaved on camera, and just minutes before the scene was shot, she shaved the head of her friend, director Yorgos Lanthimos.
Aidan Delbis improvised the part where he asks to use the bathroom during the tense dinner scene
Yorgos Lanthimos asked composer Jerskin Fendrix to create the scores for Povere creature! (2023) & Kinds of Kindness (2024), by reading the scripts without seeing any footage of the films. For Bugonia (2025), Lanthimos did not provide the script, giving Fendrix only four key words to work with: "Bees. Basement. Spaceship. Emily-bald."
For screenings in Los Angeles, attendees could enter for free, but only if they were bald or agreed to shave their head on-site. Emma Stone revealed in an interview that it was her idea.