Madeleine Stowe, who played Kathryn Railly in Twelve Monkeys (1995) does a cameo in season two.
The psychiatric center in which Jennifer is placed is called "J.D. Peoples Psychiatric Treatment Center", named after the writers of Twelve Monkeys (1995), Janet and David Peoples.
Jennifer's pet turtle is named Terry after the shows creator Terry Matalas.
The show, much like its film counterpart, is based on the short film La jetée (1962). This film also served as an influence on films such as The Terminator (1984) and The Jacket (2005).
In Twelve Monkeys (1995), the main title song used for the film was by Astor Piazzolla, called "Suite Punta Del Este". This same song can be heard in season two, episode nine, "Hyena", of this show.