- During a Reddit "Ask Me Anything" session in June 2014, Krumholtz revealed that a few years earlier he had had thyroid cancer, and in the course of his treatment, his thyroid had been removed. He said that since then, it has been a struggle to regulate his weight, but he has so far had no recurrence of cancer.
- Good friend of Colin Hanks, and got him a role on Numb3rs (2005).
- He is of Polish Jewish and Hungarian Jewish descent. His father is American and his mother left Hungary in 1956. David had a Bar Mitzvah ceremony.
- Was awarded an honorary Associates of Arts degree in Mathematics from Lake Tahoe Community College in 2007 in recognition of his work on the TV show Numb3rs (2005).
- Good friends with Judd Apatow.
- Played Neil in the original pilot for the comedy series Suddenly Susan (1996). After the pilot was shot, the format of the show was changed and the character later became Todd Stites and went to David Strickland.
- Married Vanessa Britting at The Plaza Hotel in New York City. Among the 180 guests were Rob Morrow, Judd Hirsch and Peter MacNicol.
- Has previously worked with his Numb3rs (2005) co-stars Judd Hirsch in Conversations with My Father (1992), a Broadway play, and with Peter MacNicol in "Addams Family Values" (1993).
- Attended New York University.
- Father - Michael worked for the US Postal Service; Mother - Judy was a dental assistant; older sister Dawn (born 1972).
- Daughter Pemma and son Jonas.
- Lives in Los Angeles, California.
- Attended Stephen A. Halsey Junior High School in Forest Hills, Queens.
- Engaged to Vanessa Britting (June 2008).
- The surname of his character in The Deuce, Wasserman is the same as name of the test for syphilis.
- Long term partner of Vanessa Britting.
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