- Was managing editor of "Vanity Fair" magazine from 1932-1934.
- Conceived "Life Magazine", which her husband Henry Luce would publish with great success.
- Warned FBI about the attack on Pearl Harbor. They unfortunately did not believe her.
- Clare Boothe Luce was appointed U.S. Ambassador to Italy by President Dwight D. Eisenhower in 1953, and served until 1956.
- Is credited with being the first to discover Russian missiles in Cuba in 1962, through her private surveillance efforts.
- Husband Henry Luce was the founder and publisher of Time magazine.
- Republican US Congressional representative from Connecticut, 3 January 1943-3 January 1947. Was not a candidate for renomination in 1946.
- Had lifelong love affair with Bernard Baruch.
- Her hobby was doing jigsaw puzzles.
- Was Time magazine's war correspondent during World War II.
- After graduating from high school at 16, Clare left home and found a job with a company that manufactured paper novelties.
- Announcing the nominees for Best Director at the Oscars in 1952, Luce did not know how to pronounce John Huston's name. She said, "and - and - is it John Huss-ton or John Hoo - ston?".
- Biography in: "The Scribner Encyclopedia of American Lives". Volume Two, 1986-1990, pages 557-559. New York: Charles Scribner's Sons, 1999.
- Inducted into the Connecticut Women's Hall of Fame in 1994.
- Devout convert to Roman Catholicism.
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