Uma Thurman and Joe Manganiello in The Kill Room (2023)

Joe Manganiello and Cody Kearsley in Daybreak (2019)

Justina Machado and Joe Manganiello in One Day at a Time (2017)

Jennifer Love Hewitt and Joe Manganiello in The Late Late Show with James Corden (2015)

Stephen Colbert and Joe Manganiello in The Late Show with Stephen Colbert (2015)

Conan O'Brien and Joe Manganiello in Conan (2010)

Drea de Matteo and Joe Manganiello in Nonnas (2025)

Vince Vaughn, Drea de Matteo, and Joe Manganiello in Nonnas (2025)

Joe Manganiello in Where There's a Will, There's a Way (2025)

Joe Manganiello and Charli XCX in Watch What Happens Live with Andy Cohen (2009)

Samuel L. Jackson, Uma Thurman, and Joe Manganiello in The Kill Room (2023)

Arnold Schwarzenegger, Terrence Howard, Mireille Enos, Joe Manganiello, Olivia Williams, and Sam Worthington in Sabotage (2014)

Matt Bomer, Joe Manganiello, Kevin Nash, Adam Rodriguez, and Channing Tatum in Magic Mike XXL (2015)

Anna Paquin, Alexander Skarsgård, Joe Manganiello, and Stephen Moyer in True Blood (2008)

Joe Manganiello, Tanna Frederick, Kelly De Sarla, and Rob Mathes in Irene in Time (2009)