- Studied acting at the Hochschule für Schauspielkunst "Ernst Busch" in Berlin from 1977 to 1980.
- Mother of Klara Manzel (with Peter-Mario Grau).
- Lives in Berlin with her husband Marcus Kaloff and their two children.
- Her parents were teachers.
- She has played the daughter of Christine Schorn in two films (Frei nach Plan (2007) and Hoffnung für Kummerow (2009)), even though Ms. Schorn is only 14 years older than Ms. Manzel.
- On the first edition of the "German Actor Award" held during the Berlin Film Festival on 12 February 2012, she won the Award in the category "Best Supporting Actress for Cracks in the Shell (2011) and Zettl (2012).
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