- Daughter of Arnold Spielberg and Leah Adler.
- Sister-in-law of Kate Capshaw.
- Aunt of Theo Spielberg, Sasha Spielberg, Sawyer Spielberg, Mikaela George Spielberg, Destry Allen Spielberg, and Max Spielberg.
- Daughter-in-law of David Opatoshu.
- Former sister-in-law of Amy Irving.
- Her brother Steven was originally going to direct Big (1988) which she co-wrote and produced, but his friend and collaborator George Lucas needed him to begin working on Indiana Jones and the Last Crusade (1989) and he was contractually obligated to do so. Eventually former TV actress Penny Marshall was hired instead to direct the film. It was the first movie domestically to gross over $100 million directed by a woman.
- Granddaughter-in-law of Joseph Opatoshu.
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