- (1896) Novel: "Joan of Arc"
- (1880) Novel: "A Tramp Abroad"
- (1876) Novel: "Tom Sawyer" (filmed as Tom Sawyer (1973), Tom Sawyer (2000), Tom Sawyer (1917), Tom Sawyer (1930), Tom Sawyer (1973), Tom Sawyer (1907), Tom Sawyer (1907), The Adventures of Tom Sawyer (1938)
- Novel: "Huckleberry Finn" (filmed as The Adventures of Huckleberry Finn (1960)).
- (1889) Novel: "A Connecticut Yankee in King Arthur's Court" (filmed as A Connecticut Yankee in King Arthur's Court (1949), A Connecticut Yankee (1931), Bugs Bunny in King Arthur's Court (1978), A Connecticut Yankee in King Arthur's Court (1970), Unidentified Flying Oddball (1979), Novye priklyucheniya yanki pri dvore korolya Artura (1989), A Connecticut Yankee in King Arthur's Court (1989), A Young Connecticut Yankee in King Arthur's Court (1995), A Kid in King Arthur's Court (1995), A Knight in Camelot (1998), Black Knight (2001), A Connecticut Yankee in King Arthur's Court (1954))
- Novel: "The Celebrated Jumping Frog of Calaveras County"
- Book: "Life on the Mississippi"
- Story: "The Million Pound Bank Note" (filmed as Man with a Million (1954))
- Novel: "The Prince and the Pauper" (filmed as The Prince and the Pauper (1937), The Prince and the Pauper: The Pauper King (1962), The Prince and the Pauper: The Merciful Law of the King (1962), The Prince and the Pauper: Long Live the Rightful King (1962), The Prince and the Pauper (1957), The Prince and the Pauper (1960), The Prince and the Pauper/Strange Bedfellows (2009),
- (1894) Novel: "The Tragedy of Pud'dnhead Wilson" (filmed as Pudd'nhead Wilson (1916), Pudd'nhead Wilson (1984))
- Story: The Mysterious Stranger" (filmed as The Mysterious Stranger (1982)).
- (March 28, 1921 to April 3, 1921) His novel, "The Prince and the Pauper," was performed at the Hanna Theater in Cleveland, Ohio with William Faversham (Miles Hendon); Ruth Findlay (Prince Edward Tudor and Pauper Tom Canty) in the cast.
- (2004) His novel inspired the musical, "Big River," in a Center Theatre Group and Deaf West Theatre presentation at the Roundabout Theatre Company in New York City. Roger Miller was composer and lyricists. William Hauptman wrote the book. Todd Haimes, Ellen Richard, Julia C. Levy, Ed Waterstreet and Bill O'Brien were producers.
- (January 3 to February 3, 1996) His novel, "The Adventures of Huckleberry Finn," was performed at the Actors Theatre of Louisville in Louisville, Kentucky with Leo Marks (Huckleberry Finn); Bernard Addison (Jim); Jennifer Hubbard (Miss Watson, Mrs. Grangerford, Aunt Polly, Ensemble); Adale O'Brien (Widow Douglass, Mrs. Loftus, Aunt Sally); Hamish Linklater (Tom Sawyer, Buck Grangerford); Libby Christophersen (Joe, Sophia Grangerford, Mary Jane Wilkes, Ensemble); Deborah Elz (Ben, Joanna Wiles, Ensemble); Master Trapper Michael (Tommy, Bob Grangerford, Boy Fishing, Ensemble); Bob Burrus (Pap Finn, "The King"); Mark Sawyer-Dailey (Lafe, Fool, Doctor, Ensemble); Fred Major (Frank, Dr. Robinson, Hired Hand, Ensemble); Gavin C. Whitsett (Bill, Hired Hand, Ensemble); William McNulty (Colonel Grangerford, "The Duke"); Milton Carney (Judge Thatcher, The Judge, Uncle Silas, Ensemble) and Phillip Cherry (Professor Ingram, Ensemble) in the cast. Randal Myler was adapter and director.
- (October 4 to 29, 2011) His novel, "The Adventures of Tom Sawyer," was adapted by Laura Eason in a Brown-Forman Series production at the Actors Theatre of Louisville in Louisville, Kentucky with Joseph Adams (Muff Potter/Ensemble); Justin Fuller (Joe Harper/Ensemble); Tim McKiernan (Tom Sawyer); Michael D. Nichols (Injun Joe/Ensemble); Robbie Tann (Huckleberry Finn/Ensemble); Hayley Treider (Becky Thatcher); Nate Trinrud (Sid/Doc Robinson/Ensemble) and Nance Williamson (Aunt Polly/Ensemble) in the cast. Jeremy B. Cohen was director.
- (2014 to 2015 season) Jeffrey Hatcher's stage adaptation of his novel, "A Connecticut Yankee in King Arthur's Court," was performed in The Acting Company in association with the Guthrie Theater at the Tyrone Guthrie Theater, Dowling Studio, Minneapolis, Minnesota. Joe Dowling was artistic director.
- (October 1999) His novel, "The Adventures of Huckleberry Finn,: was performed in an Oregon Shakespeare Festival Play Reading In-House production at the Black Swan Theatre in Ashland, Oregon. Libby Appel was artistic director. Scott Kaiser was adapter.
- (June 24, 2004 to August 29, 2004) His novel was the basis for the musical, "Tom Sawyer," at the New Theatre Restaurant in Overland Park, Kansas with Lyndsey Argon (Naomi Peters); Devin Amos (Lucy Wain); Kelli Berry (Sally Bellamy); Lori Blalock (Aunt Polly); Debra Bluford (Widow Douglas); Robert Gibby Brand (Mark Twain, Pap); Ashley Burns (Becky Thatcher); Charles Fugate (Lanyard Bellamy, Doc Robinson); David Gomez (Alfred Rogers); Leah Hamilton (Sereny Harper); Trevor Houston (Sidney Sawyer); Katie Hunter (Susie Hartley); Jessica Ims (Sabina Bellamy); Jim Korinke (Judge Thatcher); Eric Magnus (Gideon Wain); Vincent Onofrio Monaschino (Lemuel Dobbins); Carolyn Money (Jessica Rogers); Jeff Newman (Joe Harper); Nathan Norcross (Lyle Peters); Paula Prosser (Amy Lawrence); Michael Linsley Rappaport (Reverend Sprague); Hank Rector (Sheriff); Brian Sears (Huckleberry Finn); Josh Shirley (Muff Potter); Stephan Stubbins (Tom Sawyer); Matt Williams (George Peters); Spencer Wilson (Ben Rogers) and James Andrew Wright (Injun Joe) in the cast. Richard Carrothers and Dennis D. Hennessy were artistic directors. Ken Ludwig was developer and adapter. Don Schlitz was composer and lyricist. Richard Carrothers was also director. Joe R. Fox III was producer. Randy B. Winder was lighting designer. Keith Brumley was scenic designer. Mary Traylor was costume designer. Deborah Morgan was properties designer. Roger Stoddard and Brian R. Davidson were also sound designers. Ryan K. Klein was company manager. Kathy Stengel was stage manager. Rich Bittner was choreographer. Mark Ferrell was music director. Duane A. Hoberg was technical director. Eddie Ocheskey was resident technician. Brian R. Davidson was also audio engineer. Charlie Ream was master carpenter.
- (Summer 2014) David Ives' stage adaptation of his story, "Is He Dead?," was performed at the Pioneer Playhouse in Danville, Kentucky.
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