- Her father, Victor Yustman, was born in Bogotá, Colombia, to a Polish Jewish father and an Italian mother. He was raised in Nicaragua. Her mother, Lydia (Nodarse) Yustman, is Cuban. Odette is fluent in Spanish.
- Gave birth to her first child at age 30, daughter Charlie Mae Annable, on September 7, 2015. Child's father is her husband, Dave Annable. The couple met when she guest-starred with him during a five-episode character arc on Brothers & Sisters (2006). They wed on October 10, 2010.
- Attended Riverside (CA) Community College and Riverside (CA) Christian School.
- Ranked #88 in "FHM" Magazine's Sexiest Women in the World List of 2008.
- She is a huge fan of Angelina Jolie.
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