- Has developed a reputation for being extremely approachable and friendly to fans who meet him on the streets.
- Is an aspiring photographer.
- While filming Looney Tunes: Back in Action (2003), was terrified at having to hit Bill Goldberg. Goldberg constantly told him to go ahead and do it, telling him, "It's what I do for a living."
- Has dual citizenship: American and Canadian.
- Raised in Holland, Switzerland, and Canada. Educated at Upper Canada College in Toronto, the Actors' Conservatory, Cornish College of the Arts in Seattle.
- Chosen by People Magazine as one of the 50 most beautiful people in the world. (1998)
- He was the first choice for playing the lead role in Inspector Gadget (1999), but the role ultimately went to Matthew Broderick. Fraser had to turn down the role in favor to perform as the title character in George of the Jungle (1997).
- Was considered for the role of Phil Dunphy on Modern Family (2009).
- Has recorded more than a few plays for broadcast on the radio, including works by Tennessee Williams and Eugene O'Neill.
- Whenever appearing in a Pauly Shore movie, he uses the character name "Link".
- Was set to play the role of Dr. Steve/Eddie in The Wedding Planner (2001), but scheduling conflicts with filming Bedazzled (2000) prevented him. The role went to Matthew McConaughey.
- He welcomed first child son Griffin Arthur on September 17, 2002.
- Attended Cornish College of the Arts in Seattle, Washington.
- His parents are Canadian, his father from Saskatchewan and his mother from Nova Scotia. He has Irish, Scottish, German, Czech, French-Canadian, and English ancestry.
- Listed on the 2017 Primetime Emmy Awards Nominating Ballot for Performers (in the Supporting Actor In A Drama Series category) for The Affair (2014).
- He is the first actor to play the DC Comics character Cliff Steele/Robotman in a live-action adaptation.
- Was considered for the role of Dr. Reed Richards/Mr. Fantastic in Fantastic Four (2005).
- Has three older brothers: Kevin Fraser, Sean Fraser and Regan Fraser.
- Wife Afton gave birth to their third child and third son, Leland, on May 2, 2006 in Los Angeles, California.
- He was in consideration to play Superman Returns (2006) when Brett Ratner was still attached to the film.
- The son of a Canadian travel executive. Among the places he lived in his younger days include Cincinnati, Ohio; Detroit, Michigan; Ottawa, Canada; and Holland.
- Second child, son Holden Fletcher, b. 16 August 2004
- Appearing in the stage version of "Cat on the Hot Tin roof" in London. (December 2001)
- He is not ambidextrous as it might appear in Monkeybone (2001). If you listen to the director's commentary, that is a left hand artist's hand seen painting the characters, and the artist isn't Brendan.
- His and ex-wife Afton's wedding was held in the garden at the Bel Air Hotel in Los Angeles.
- Fraser actually wrestled with Joseph the Lion during his role of George of the Jungle. Joseph's trainer, Charlie Sammut, more interacted with his younger trained male African lion, Caleb. Their scene was filmed in Playa Vista, California's former Hughes Airport hangar. Both lions were residents of Salinas, California's Monterey Zoo at the time of that cinematic production.
- Parents: Carol Fraser and Peter Fraser.
- In Singapore for the 3-D film fest. The first film festival specifically dedicated to 3-D technology (3DX: 3D Film & Entertainment Technology Festival). (November 2008)
- He along with John Hannah are the only actors to appear in all 3 films in The Mummy Trilogy 1999-2008.
- His surname is pronounced "Fraze-er".
- He has appeared in two films that have been nominated for the Best Picture Oscar: Crash (2004) and Killers of the Flower Moon (2023). The former won in the category.
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