- (1993) Books On Tape--Stephen King's "Nightmares & Dreamscapes, Volume #1" Segment, "Dolan's Cadillac".
- (October 1984) Release of the music video for "Turn to You" by The Go-Go's, with appearance Rob Lowe, directed by Mary Lambert.
- (2001) Print ads for Skechers footwear.
- (August 2005 - December 2005) "A Few Good Men," dramatic revival; written by Aaron Sorkin; directed by David Esbjornson; with Rob Lowe (portraying LTJG Daniel Kaffee); Suranne Jones (portraying LCDR Galloway); and John Barrowman (portraying LT. Ross); on the West End at the Theatre Royal Haymarket, London, England, UK.
- TV commercial (voice-over) for Mazda cars.
- (2007) TV commercial for the California Travel & Tourism Board.
- (April 2011) Release of his memoir, "Stories I Only Tell My Friends," published by Henry Holt & Company, Manhattan, New York City, New York, USA.
- (June 10, 1985) Guest on "Live on Five," WEWS-TV, Cleveland, Ohio, USA.
- (July 2014 - August 2014) TV commercial for the Discovery Channel's "Shark Week" programming.
- (September 2014) TV commercial, "Me, and Less Attractive Me," for Direct TV.
- (October 2014) In a commercial for DirecTV.
- (April 2017) "Can you actually launch KFC's world-famous Zinger chicken sandwich into space?" Lowe says in a new 90-second digital spot for Kentucky Fried Chicken.
- (2017) TV commercial for Skechers Relaxed Fit shoes
- (2018) TV commercial for Atkins Diet snack bars
- (July 1985) Appears in the music video "St. Elmo's Fire (Man In Motion)"
- (2023) TV commercial: Atkins Diet snack bar with Wanda Sykes
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