Kirstie Alley and Alison La Placa in Madhouse (1990)

Kirstie Alley, Alison La Placa, and John Larroquette in Madhouse (1990)

Kirstie Alley, Bradley Gregg, and John Larroquette in Madhouse (1990)

Kirstie Alley, Woody Harrelson, and Ted Danson in Cheers (1982)

Kirstie Alley in Saturday Night Live (1975)

Kirstie Alley in The Roseanne Show (1997)

Kirstie Alley and Roseanne Barr in The Roseanne Show (1997)

Kirstie Alley, Walter Koenig, William Shatner, Bibi Besch, DeForest Kelley, George Takei, Merritt Butrick, and Nichelle Nichols in Star Trek II: The Wrath of Khan (1982)

Kirstie Alley, Walter Koenig, William Shatner, DeForest Kelley, and Paul Winfield in Star Trek II: The Wrath of Khan (1982)

Kirstie Alley, Walter Koenig, Leonard Nimoy, William Shatner, James Doohan, DeForest Kelley, George Takei, and Nichelle Nichols in Star Trek II: The Wrath of Khan (1982)

Kirstie Alley and Merritt Butrick in Star Trek II: The Wrath of Khan (1982)

Jamie Lee Curtis, Brooke Shields, Kirstie Alley, John Stamos, Emma Roberts, and Abigail Breslin in Scream Queens (2015)

Kirstie Alley and Emma Roberts in Scream Queens (2015)

Jamie Lee Curtis and Kirstie Alley in Scream Queens (2015)

Kirstie Alley and Lindsay Parker in Infidelity (1987)

Kirstie Alley and Lee Horsley in Infidelity (1987)

Kirstie Alley, Lee Horsley, and Lindsay Parker in Infidelity (1987)

Kirstie Alley in TCM Remembers 2022 (2022)

Woody Allen, Elisabeth Shue, Robin Williams, Kirstie Alley, Billy Crystal, Mariel Hemingway, Julia Louis-Dreyfus, Richard Benjamin, Tobey Maguire, and Stanley Tucci in Deconstructing Harry (1997)

Kirstie Alley, Ellen Barkin, Kirsten Dunst, and Denise Richards in Drop Dead Gorgeous (1999)

Kirstie Alley, Steve Guttenberg, Ashley Olsen, Mary-Kate Olsen, and Jane Sibbett in It Takes Two (1995)

John Travolta, Bruce Willis, Kirstie Alley, Danny DeVito, Diane Keaton, David Gallagher, and Tabitha Lupien in Look Who's Talking (1989)

Kirstie Alley, Barbara Carrera, Carrie Fisher, Kate Jackson, and Patrick Dempsey in Loverboy (1989)

Kirstie Alley and Steven Ivany in David's Mother (1994)

Kirstie Alley, Mark Harmon, and Courtney Thorne-Smith in Summer School (1987)

Kirstie Alley, Woody Harrelson, Ted Danson, and Kelsey Grammer in Cheers (1982)