- Is a first-generation American. His parents, Mario and Rose Baio, both emigrated to the United States from Italy.
- Made his directorial debut on his sitcom Charles in Charge (1984), where he directed many episodes, credited under his full name Scott Vincent Baio.
- In the fall of 1998, he starred in a sitcom called "Rewind" which had been picked up by FOX. However, the network canceled the series before a single episode made it to air.
- Left his role on Diagnosis Murder (1993) at the end of the second season, to look for other projects, he was replaced by Charlie Schlatter, who stayed with his role until the series' cancellation.
- Is a registered Republican. In 2004, he attended former President Ronald Reagan's funeral at the Reagan Library in Simi Valley, California.
- Best known by the public for his role as Chachi Arcola on Happy Days (1974), and starring roles as the title character in Charles in Charge (1984) and as David Hobbs in See Dad Run (2012).
- Has highly praised Marion Ross for his stardom in acting.
- Daughter, Bailey Deluca Baio, was born on November 2, 2007, weighing 5 pounds, 10 ounces. She arrived five weeks early. Her mother is Renee Baio.
- Actress Marion Ross took him under her wing, when he was age 17.
- Endorsed Donald Trump for president again in 2024.
- Attended and graduated from Xaverian High School in Bay Ridge, Brooklyn, New York.
- As an actor, he was highly influenced by Marion Ross.
- Ranked #16 in TV Guide's list of "TV's 25 Greatest Teen Idols" (23 January 2005 issue).
- Was engaged to graduate student Janette Jonasson as of July 18, 2001, but has since broken off the engagement.
- Ranked #18 on VH1's 100 Greatest Teen Stars.
- Inducted into The Man Show Hall of Fame for his reputation of dating women such as Brooke Shields and Pamela Anderson.
- A rumor circulated that he had been killed in a car crash. It was never determined how the rumor started, but it turned out that Baio hadn't even been in an accident, much less gotten killed in one. (December 18, 1997)
- Endorsed Republican presidential candidate Donald Trump during Trump's 2016 presidential campaign, and spoke at the opening night of the 2016 Republican National Convention in support of Trump.
- Attended Saint Bernadette Elementary School in Dyker Heights, Brooklyn, New York.
- Since he had dated three of the girls from the golden age of Baywatch (Nicole Eggert, Pamela Anderson, Erica Eleniak), his friends would kid him, and call it Baiowatch. (as told to Howard Stern on the radio, 1994).
- The 26 May 1982 issue of Variety magazine, in the "Film Production Chart" section, lists an independent movie called Hi-Jinx that started filming 24 May 1982 starring Scott Baio, Leif Garrett. Producer was David Gil, director James Komak, script Barry Roberts and Allen Stone. The movie was evidently never released.
- Stepfather of Kalyn LaNae' Sloan (born 1989).
- Endorsed Republican presidential candidate Mitt Romney during Romney's 2012 presidential campaign.
- Scott and Fox Business host Maria Bartiromo grew up in the same Brooklyn neighborhood, Bay Ridge.
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