- Granddaughter of Melvyn Douglas.
- She has appeared in four films directed by Martin Scorsese: The Last Temptation of Christ (1988), New York Stories (1989), Goodfellas (1990) and Cape Fear (1991).
- Was in a relationship with Martin Scorsese from 1988 to 1997.
- She can be seen playing the role of Aerosmith's band manager in the hologram video used on the "Rock n Roller Coaster" ride in the Hollywood Studios theme park at Disney World in Orlando.
- Illeana won Best Actress "The Green" at the 2011 Williamsburg Independent Film Festival.
- Ms. Douglas trained for two years (1981 to 1983) at The American Academy of Dramatic Arts in NYC before attending Neighborhood Playhouse.
- Her father has English, German, Scottish, and one quarter Latvian Jewish, descent. Her mother is of Romanian and Italian ancestry.
- Former daughter-in-law of George Axelrod and Joan Axelrod. Former sister-in-law of actress Nina Axelrod.
- Graduated from Haddam-Killingworth High School in Higganum, Connecticut, class of 1979.
- First cousin of actress Ele Keats.
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