- Godfather of Jennifer Garner and Ben Affleck's daughter Violet.
- Not only was he the one and only guest at Alias (2001) co-star Jennifer Garner and Ben Affleck's wedding, but he officiated at the ceremony after learning how to do so on the Internet.
- As of 2017, he has appeared in three films that were nominated for the Academy Award for Best Picture: Titanic (1997), Milk (2008) and Argo (2012). Titanic (1997) and Argo (2012) are winners in the category.
- Played the uncredited role as assistant bank manager in friend Ben Affleck's movie The Town (2010).
- Was lead singer of Toronto pop group Sugar Shoppe.
- Diagnosed with Type 1 diabetes at age 12.
- He studied drama at HB Studio in Greenwich Village in New York City, and still lives in the neighborhood.
- Has played both Jesus (in Godspell) and the Devil (in Damn Yankees) in major stage productions.
- Has been nominated for Broadway's Tony Award four times: as Best Actor (Featured Role -Play) in 1978 for "Deathtrap;" as Best Actor (Musical) in 1982 for a revival of "Little Me" and in 1994 for a revival of "Damn Yankees!"; and as Best Actor (Play) in 1989 for "Lend Me a Tenor."
- Originated the role of Clifford Anderson in the 1978 New York City production of "Deathtrap."
- License plate on his on-set bike at Disney is "SPYDAD."
- Is in a long-term romantic relationship with artist, model, and fellow Canadian Rainer Andreesen. When they got married in 2015, they had been together for 16 years.
- He has a brother and a sister. His mother was Hope Garber, who died in 2005; his father passed away in 1993.
- Originated the role of Anthony in the 1979 Stephen Sondheim musical "Sweeney Todd, the Demon Barber of Fleet Street."
- Is a close friend of Ben Affleck. Both Affleck and Garber have portrayed DC comic book characters. Affleck is portraying Batman in the upcoming film "Batman v Superman: Dawn Of Justice" (2016) while Garber plays Dr. Martin Stein in the TV series "The Flash" (2014).
- Received Tony Award nominations for "Deathtrap" (Featured Actor), "Little Me' (Actor - Musical), "Lend Me a Tenor" (Actor), and "Damn Yankees" (Actor - Musical).
- Jack Bristow, Garber's character on Alias (2001), was ranked #29 in TV Guide's list of the "50 Greatest TV Dads of All Time" [20 June 2004 issue].
- Originated the role of John Wilkes Booth in the 1990 Stephen Sondheim musical "Assassins".
- New York, NY, USA: Living with his partner of 13 years, artist Rainer Andreesen. (January 2013)
- In 2008, he co-presented a gallery show for his longtime companion (and now husband), the Canadian-born, LA and New York-based portrait painter Rainer Andreesen.
- Friends with Jennifer Garner.
- He has played the same character (Dr. Martin Stein) in five different series: Arrow (2012), The Flash (2014), Supergirl (2015), Vixen (2015) and DC's Legends of Tomorrow (2016).
- Starring in Noel Coward's Present Laughter for the Roundabout theatre company in New York City. (January 2010)
- He was awarded the O.C. (Officer of the Order of Canada) on November 9, 2022 from the Canadian Governor General. He lives between New York City and Canada.
- Born on exactly the same date as Erik Estrada of "CHiPs" fame.
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