Katherine Heigl and Sarah Chalke in Firefly Lane (2021)

Katherine Heigl and Alexa Havins in 27 Dresses (2008)

Harry Connick Jr., Katherine Heigl, and Madison Iseman in Fear of Rain (2021)

Katherine Heigl and Sarah Rafferty in Suits (2011)

Katherine Heigl and Gabriel Macht in Suits (2011)

Katherine Heigl and T.R. Knight in Grey's Anatomy (2005)

Katherine Heigl and Ken Marino in Grey's Anatomy (2005)

Katherine Heigl and Brendan Fehr in Roswell (1999)

Katherine Heigl and Dulé Hill in Doubt (2017)

Katherine Heigl and Judith Light in Doubt (2017)

Gérard Depardieu and Katherine Heigl in My Father the Hero (1994)

Katherine Heigl, Jason Behr, Shiri Appleby, and Brendan Fehr in Roswell (1999)

Katherine Heigl, Jason Behr, Majandra Delfino, Shiri Appleby, and Brendan Fehr in Roswell (1999)

Katherine Heigl, Jason Behr, Emilie de Ravin, and Brendan Fehr in Roswell (1999)

Patrick Dempsey, Katherine Heigl, Justin Chambers, Sandra Oh, James Pickens Jr., Ellen Pompeo, Isaiah Washington, Chandra Wilson, and T.R. Knight in Grey's Anatomy (2005)

Katherine Heigl and Seth Rogen in Knocked Up (2007)

Katherine Heigl, Mena Suvari, Breckin Meyer, and Marsha Thomason in Caffeine (2006)

Patrick Dempsey, Katherine Heigl, Kate Walsh, Justin Chambers, Eric Dane, Sandra Oh, James Pickens Jr., Ellen Pompeo, Sara Ramirez, Isaiah Washington, Chandra Wilson, and T.R. Knight in Grey's Anatomy (2005)