John Goodman, Sara Gilbert, Michael Fishman, Alicia Goranson, and Laurie Metcalf in The Talk (2010)

Sara Gilbert and Ames McNamara in The Conners (2018)

Juliette Lewis, Sara Gilbert, and Emma Kenney in The Conners (2018)

Juliette Lewis and Sara Gilbert in The Conners (2018)

Sara Gilbert and Justin Long in The Conners (2018)

Sara Gilbert, Alicia Goranson, and Justin Long in The Conners (2018)

Sara Gilbert, Alicia Goranson, Justin Long, and Marques Ray in The Conners (2018)

Sara Gilbert, Alicia Goranson, and Laurie Metcalf in The Conners (2018)

Sara Gilbert, Laurie Metcalf, and Emma Kenney in The Conners (2018)

John Goodman, Sara Gilbert, Alicia Goranson, and Laurie Metcalf in The Conners (2018)

Sara Gilbert and Laurie Metcalf in The Conners (2018)

Sara Gilbert and Alicia Goranson in The Conners (2018)

John Goodman, Roseanne Barr, Sara Gilbert, Michael Fishman, Alicia Goranson, and Laurie Metcalf in Roseanne (1988)

Sara Gilbert and Johnny Galecki in Roseanne (1988)

Sara Gilbert and Alicia Goranson in Roseanne (1988)

Roseanne Barr and Sara Gilbert in Roseanne (1988)

Leonardo DiCaprio, Sara Gilbert, and Jenny Beck in Roseanne (1988)

Sara Gilbert, Julie Chen Moonves, Sharon Osbourne, Aisha Tyler, and Sheryl Underwood in The Talk (2010)

Kristin Davis, Sara Gilbert, David Alan Grier, Ari Graynor, Ryan Hansen, and Sara Rodier in Bad Teacher (2014)

Christine Baranski, Sara Gilbert, Rocky Carroll, and Jim Gaffigan in Welcome to New York (2000)

John Goodman, Roseanne Barr, Sara Gilbert, Sarah Chalke, Michael Fishman, Alicia Goranson, and Laurie Metcalf in Roseanne (1988)

Drew Barrymore, Tom Skerritt, Cheryl Ladd, and Sara Gilbert in Poison Ivy (1992)

Drew Barrymore, Alyssa Milano, Tom Skerritt, Belinda Bauer, Cheryl Ladd, Camilla Belle, Sara Gilbert, Jaime Pressly, Xander Berkeley, Megan Edwards, and Greg Vaughan in Poison Ivy (1992)