- Real-life wife Maureen Van Zandt plays the wife of his character, Silvio Dante, on The Sopranos (1999).
- He and wife Maureen Van Zandt were married by (Reverend) Little Richard, with a wedding reception band consisting of Bruce Springsteen and the E Street Band, Gary U.S. Bonds, Little Milton and the wedding band from The Godfather (1972).
- Told "People" magazine that he had no desire to act in any other roles in spite of rave reviews for his portrayal in The Sopranos (1999).
- At his wedding to Maureen, not only was the classic marital song "When a Man Loves a Woman" performed, it was sung live by Percy Sledge who had a hit with the record in 1966.
- Is a member of Bruce Springsteen's E-Street Band.
- Adopted his professional surname "Van Zandt" from his stepfather. He has said, "Though my last name is Dutch, I'm 100 percent Italian".
- Long-time friend of Bruce Springsteen, playing with Springsteen's early bands (Steel Mill and The Bruce Springsteen Band), but didn't join the E-Street Band until the "Born to Run" tour in 1975.
- He and the E Street Band (including Gary Tallent, Vini Lopez, David Sancious, Max Weinberg, Roy Bittan, Nils Lofgren, Patti Scialfa, Ernest "Boom" Carter, the late Clarence Clemons, and the late Danny Federici) were inducted into the 2012 New Jersey Hall of Fame for their services and contributions to music.
- He was inducted into the 2017 New Jersey Hall of Fame in the Performing Arts category.
- Reprised his Sopranos character, Silvio Dante in a commercial for World of Warcraft. Citing his famous quote from The Godfather "Just when I thought I was out, they pull me back in!".
- Host of "Little Steven's Underground Garage" a late night radio program on Sunday nights 10pm-Midnight (2002-
- Brother-in-law of Adrienne Barbeau.
- Introduced as the Minister of Faith and Friendship, keeper of all that is righteous in the E-Street Band and star of The Sopranos (1999) television show, "Little" Steven Van Zandt on the "Live in New York" album with Bruce Springsteen & The E Street Band.
- Older half-brother of Billy Van Zandt.
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