- Starred alongside Bernie Mac in Soul Men (2008). It was to be their last film as they sadly passed away within a day of each other, Bernie on the 9th August 2008 and Isaac on the 10th August 2008.
- His performance as "Chef" in the TV series South Park (1997) was supposed to be a one-time event, but audience reaction was so positive, "Chef" became a regular character.
- His character, "Chef", was killed off South Park (1997) after his resignation for religious reasons.
- First African American composer to win an Oscar for Best Original Song (1972) for The Theme from Shaft (1971).
- Suffered a stroke in January 2006.
- Inducted into the Songwriters Hall of Fame on June 9, 2005 in New York City alongside Robert B. Sherman, Richard M. Sherman, Bill Withers, John Fogerty, Steve Cropper and longtime collaborator David Porter.
- Inducted into the Rock and Roll Hall of Fame in 2002.
- Was originally considered for the role of Shaft (1971), but the lead went to Richard Roundtree. He got the lead role in Truck Turner (1974), the only film in which he ever played such a part.
- Was pronounced dead at 2:08 pm at Baptist Memorial Medical Hospital in Memphis, Tennessee on August 10, 2008.
- Filed for bankruptcy in 1976.
- Has been a frequent songwriting collaborator with David Porter since 1962.
- Father of Heather Hayes, Isaac Hayes III, Veronica Hayes, Jackie Hayes, Felicia Hayes, Melanie Hayes, Nikki Hayes, Lilli Hayes, Darius Hayes, and Vincent Hayes.
- Friend of Aretha Franklin, and Tim Reid.
- Son (b. Nana Kwadjo April 10, 2006).
- Is named among others as inspiration for the Massive Attack album "Blue Lines".
- Brother of Willette Rankin.
- Has 14 grandchildren, and three great-grandchildren.
- Buried at Memorial Park Cemetery, Memphis, Shelby County, Tennessee.
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