- Studied tap and ballet.
- O'Keefe is the youngest of three sisters and has Irish, Czech, Austrian, Polish and Swedish ancestry. She attended a co-ed Catholic school.
- Was once engaged to her Nash Bridges (1996) co-star, Don Johnson.
- Has filmed 2 movies at Torrance High School, She's All That (1999) and Whatever It Takes (2000).
- Has played patrol officers with the San Francisco Police on both Nash Bridges (1996) and The Evidence (2006).
- Likes to paint Tea Cups and give them away as gifts.
- Prefers kickboxing to stairmasters to keep in shape.
- Featured, along with Desperate Housewives (2004) star, Jesse Metcalfe, in the 3 Doors Down music video for "Let Me Go". (February 2005)
- Listens to everything from Antonio Vivaldi to Nirvana.
- Starring in Prison Break (2005), season #3-#4, as "Gretchen Morgan" (37 episodes, 2007-2009). (2007)
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