- On the sitcom Black-ish (2014), Laurence Fishburne plays his father and is actually only nine years his elder.
- One of four actors to appear in both the "Scream" franchise and its parody, the "Scary Movie" franchise. The other three are Jenny McCarthy-Wahlberg, Jerry O'Connell and Tori Spelling. Anderson is the only one to appear in the "Scary Movie" franchise before appearing in a "Scream" film.
- Son of Doris Bowman, a former telephone operator.
- Grew up in Compton, California.
- Nominated for the 2018 Emmy Award in the Lead Actor in a Comedy Series category for his role as Andre 'Dre' Johnson in Black-ish (2014), but lost to Bill Hader from Barry (2018).
- Has co-starred with DMX in three movies: Romeo Must Die (2000), Exit Wounds (2001) and Cradle 2 the Grave (2003).
- Attended Howard University in Washington, D.C.; but was forced to dropped out. Is an honorary member of Omega Psi Phi Fraternity, Inc.
- Currently resides in Los Angeles, California. He is married to his college sweetheart and they have two children.
- In Scream 4 (2011), he plays a character named Anthony Perkins, named after the actor who played Norman Bates in Psycho (1960).
- He was awarded a Star on the Hollywood Walk of Fame for Television at 6780 Hollywood Boulevard in Hollywood, California on August 14, 2020 (the day before his 50th birthday). George Lopez, Brian Robbins and his mother Doris Bowman were guest speakers at the ceremony.
- Has family residing in the Chicago, Illinois area.
- Attended Hollywood High School Performing Arts Center at the same time as Benito Martinez, his future co-star on The Shield (2002). Anderson was a year behind Martinez.
- Used the line "Don't drop the soap" in two different movies: Barbershop (2002) and King's Ransom (2005).
- Attended and graduated from Hollywood High School Performing Arts Center (1988).
- He was considered to play the Voodoo Maestro in Scooby-Doo (2002), but turned down due to schedule conflicts with Kangaroo Jack (2003). The role went to Miguel A. Núñez Jr..
- He cried the first time he did a stand-up comedy show because he got booed of the stage.
- Favorite NFL football player is Reggie Bush of the New Orleans Saints.
- His photo double in Cradle 2 the Grave (2003) was actor Dwayne Winstead.
- Attended the 2006 Dominican International Film Festival in Santo Domingo.
- He cried the first time he did a stand-up comedy show because he got booed off the stage.
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