Katherine Heigl and Sarah Chalke in Firefly Lane (2021)

Billy Crystal and Sarah Chalke in The Late Late Show with James Corden (2015)

Jason Biggs and Sarah Chalke in Mad Love (2011)

John Goodman, Roseanne Barr, Sara Gilbert, Sarah Chalke, Michael Fishman, Alicia Goranson, and Laurie Metcalf in The Talk (2010)

Sarah Chalke and Alicia Goranson in Roseanne (1988)

Sarah Chalke and Ken Jenkins in Scrubs (2001)

Travis Schuldt and Sarah Chalke in Scrubs (2001)

Zach Braff and Sarah Chalke in Scrubs (2001)

Sarah Chalke, Donald Faison, and Judy Reyes in Scrubs (2001)

Sarah Chalke and Josh Radnor in How I Met Your Mother (2005)

Sarah Chalke and Glenn Quinn in Roseanne (1988)

Sarah Chalke and Lochlyn Munro in Stand Against Fear (1996)

Jason Biggs, Sarah Chalke, Judy Greer, and Tyler Labine in Mad Love (2011)

Elizabeth Perkins, Brad Garrett, and Sarah Chalke in How to Live with Your Parents (for the Rest of Your Life) (2013)

John C. McGinley, Zach Braff, Sarah Chalke, Donald Faison, Neil Flynn, Ken Jenkins, and Judy Reyes in Scrubs (2001)

John Goodman, Roseanne Barr, Sara Gilbert, Sarah Chalke, Michael Fishman, Alicia Goranson, and Laurie Metcalf in Roseanne (1988)