- She doubled for Anthony Perkins in the legendary shower scene for Alfred Hitchcock's classic Psycho (1960). She is only onscreen for a few seconds in silhouette playing the knife-wielding "Mother". The scene, a montage of skillfully edited split second images, is arguably the most famous, discussed and analyzed scene in cinema history.
- Margo doubled for actor Anthony Perkins in the shower scene in Psycho (1960) because he was in New York rehearsing for a play. The scene lasts for only about 45 seconds but required a full week of shooting.
- Has two sisters, also actresses: Stephanie Epper and Jeannie Epper. All three sisters appeared as prostitutes in the The Life and Times of Judge Roy Bean (1972).
- Daughter of John Epper.
- Mother of Johnny Hock, who is also a stunt performer.
- Great aunt of Christopher Epper.
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