- Well-known actor Nana Patekar recommended him for the job .
- Debuted as a director with the Marathi movie Dambis (2011).
- He is married to Shilpa Anaspure Shilpa Anaspure and blessed with two children from the marriage.
- In 2015, established the Naam Foundation, along with Nana Patekar, to aid farmers overcome drought conditions in Maharashtra.
- Makarand shot to fame after having worked in Saatchya aat gharat and Kaydyach Bola.
- Anaspure is known for his ability to use the Marathwada accent of the Marathi language.
- Got an opportunity to work as an assistant director for Yeshwant (1997).
- Made his debut as a producer with the film Goshta Choti Dongraevadhi (2009).
- He completed college from Saraswati Bhuvan College in Aurangabad.
- He was host of Marathi show Assal Pahune Irsal Namune on Colors Marathi.
- He appeared in a cameo for one episode in the Hindi serial Tu Tu Main Main and as an umpire along with co-stars Bharat Jadhav and Arun Kadam.
- He judged the comedy show Fu Bai Fu.
- Makrand was host of the Marathi show Hapta Band in its second season on Zee Marathi.
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