- Directed 2 actors to an Oscar nominated performance: Natalie Portman and Kristen Stewart.
- Son of Hernán Larraín and Magdalena Matte.
- Attended an all-boys private Catholic schools: Colegio Apoquindo in Lo Barnechea and San Francisco de Asís in Las Condes.
- Graduated from UNIACC University with degree in Audiovisual Communication with a major in Cinema (1998).
- His movie No (2012) became the first Chilean picture nominated for an Academy Award as "Best Foreign Language Film".
- Founder of the production company Fabula Productions in 2004.
- Through his mother, he is related to the Alessandri family; he is a great-great-grandson of the twice Chilean President Arturo Alessandri. His great-grandmother is sister of Jorge Alessandri (26th President of Chile), and his grandfather is brother of Ester Matte Alessandri (poet).
- Member of the jury at the Venice Film Festival in 2013.
- His grandmother is sister of the artist Juana Lecaros.
- Began a relationship with actress Antonia Zegers in January 2006. They married on 9 December 2006, but separated in 2014.
- His great-grandfather, Arturo Matte, co-founded of the paper company "CMPC".
- His favorite directors are Werner Herzog, John Cassavetes, Maurice Pialat, Ingmar Bergman, Stanley Kubrick, Pier Paolo Pasolini and Yasujirô Ozu.
- He is also a photographer.
- Ex-son-in-law of Fernando Zegers and Mónica Oportot.
- Brother of Hernán Larraín Matte, Juan de Dios Larraín, Magdalena Larraín, María José Larraín and Blanca Larraín.
- Was romantically linked to Virginie Ledoyen and Natalie Portman.
- Cousin of Hernán Rodríguez Matte.
- While studying film degree, he also studied journalism.
- Close friend of Diego Muñoz.
- Was once considered to direct a remake of Scarface (1983).
- President of the jury at the Torino Film Festival in 2017.
- Was a director or producer on some 150 commercials between 2001 and 2005.
- Speaks English fluently.
- Co-owns a "Radio Isla Negra" with Hernán Rodríguez Matte, Juan de Dios Larraín, Hernán Larraín Matte, Sebastián Lelio, Piedad Rivadeneira and Sebastián Arteaga.
- In May 2014 he directed the opera "Katia Kabanová" by Leos Janácek at Santiago's Municipal Theatre.
- Had two films on the Indiewire's list of the 50 Best Films of 2016: Jackie (2016) #10 and Neruda (2016) #47.
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