Ryan Phillippe and Samaire Armstrong in The 2nd (2020)

Samaire Armstrong in The Staircase Murders (2007)

Martin Henderson, Samaire Armstrong, and Giacomo Gianniotti in Grey's Anatomy (2005)

Martin Henderson, Samaire Armstrong, Kelly McCreary, and Giacomo Gianniotti in Grey's Anatomy (2005)

Martin Henderson, Samaire Armstrong, and Kelly McCreary in Grey's Anatomy (2005)

Samaire Armstrong, Kelly McCreary, and Giacomo Gianniotti in Grey's Anatomy (2005)

Martin Henderson and Samaire Armstrong in Grey's Anatomy (2005)

Treat Williams and Samaire Armstrong in The Staircase Murders (2007)

Kevin Zegers and Samaire Armstrong in It's a Boy Girl Thing (2006)

William Baldwin, Donald Sutherland, Jill Clayburgh, Blair Underwood, Seth Gabel, Glenn Fitzgerald, Peter Krause, Natalie Zea, and Samaire Armstrong in Dirty Sexy Money (2007)

William Baldwin, Donald Sutherland, Jill Clayburgh, Seth Gabel, Glenn Fitzgerald, Peter Krause, Natalie Zea, and Samaire Armstrong in Dirty Sexy Money (2007)

Adam Goldberg, Frankie Muniz, William Brent Bell, Sophia Bush, Jon Foster, McG, Wendell Pierce, Jimmi Simpson, Milo Ventimiglia, and Samaire Armstrong in Stay Alive (2006)