- Met his wife Namrata Shirodkar on the set of his film "Vamsi".
- Tamil Actors Suriya, Karthi and Vaibhav (Mankatha, Goa Fame) are his childhood School Friends.
- One of the few actors in Indian Film Industry who never did a remake in his career.
- He was voted the 2nd Most Desirable Man for the year 2012 by The Times of India.
- Has won Seven Nandi Awards in which 3 for the Best Actor, 3 for Best Actor in Special Jury and 1 for Best Male Debut.
- Brother of Ramesh Babu Ghattamaneni and Manjula Ghattamaneni.
- He joined Farhan Akhtar's MARD campaign by supporting the cause and has also lent his voice to the poem written in Telugu.
- He was elected the 1st Most Desirable Men Of India for the year 2013 by The Times of India.
- Is a huge fan of his father Superstar Krishna and Senior actor Nandamuri Taraka RamaRao.
- Father of Gautam Krishna (born on 31 August 2006) and Sitara (born on 20 July 2012).
- Son of the Legendary Telugu Movie Actor Krishna.
- He was voted the 5th Most Desirable Men for the year 2011 by The Times of India.
- Mahesh's childhood was spent mostly in Madras under the care of his maternal grandmother, Smt. Durgamma, and the rest of his family.
- Has won 3 CineMAA awards for the Best Actor Category, which is the highest of any actor to date.
- Is very close to his family, especially to his brother Ramesh Babu.
- Mahesh Babu is the 2nd Highest Paid actor after Rajinikanth at one point.
- Mahesh Babu is known for his trademark dialogue delivery and running.
- Mahesh has given 30% of his annual income to charities, and most of his philanthropic activities are not in public because he prefers them to be so.Mahesh joined Farhan Akhtar's Men Against Rape and Discrimination (MARD) campaign in August 2013 and lent his voice to the Telugu version of a poem written by Javed Akhtar.He was signed in 2013 as the goodwill ambassador of Heal-a-child Foundation.
- Mahesh Babu is the Highest earning celebrity in the year 2015 In south India according to Forbes India.
- In October 2014, he donated 2 Crores to a relief fund run by the chief minister of Andhra Pradesh for reconstruction of areas destroyed during Cyclone Hudhud.
- He Adopted 2 Villages 1 in Andhra Pradesh and 1 in Telangana, and changing them into model villages.
- Mahesh Babu Donates For 99 poor children Heart Operations through Andhra Hospitals.
- To date, he has won seven Nandi Awards, five Filmfare Awards, three CineMAA Awards, three South Indian International Movie Awards and one International Indian Film Academy Award.
- Mahesh Babu owns a production house.
- Mahesh Babu has never gone shirtless on screen.
- He is the only actor in Telugu Cinema to have 5 Filmfare Best Actor awards in 17 years of film career (with a 3 year break).
- Mahesh is an ambassador for about a dozen of South Indian brands. In 2007, he signed a five-year endorsement deal with the cola company Thums Up to replace Chiranjeevi as its brand ambassador in Andhra Pradesh.
- Mahesh Babu can speak Telugu and Tamil fluently as he was raised in Chennai and his mother tongue is Telugu, although he cannot read and write Telugu and Tamil. As the second language which he studied while schooling other than English is Hindi.
- He was ranked twelfth on the Times' 50 Most Desirable Men in India for the year 2010. He climbed to the first position of the same list for the year 2013, beating the likes of Hrithik Roshan, Salman Khan and Shahrukh Khan.He stood at sixth place on the same list for the year 2014.
- Mahesh Babu is the most popular actor in Tollywood.
- He is the only Tollywood hero who had six 100 crores going club movies and from that he had four 200 crores going movies. He also had ten 1 million dollar movies in U.S.A.
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