- She studied drama and cultural studies at the University of West England. But Raine then took a gap year and taught English as a second language in Thailand.
- She wanted to be an actress from the age of 13.
- Married her boyfriend of 5 years, Tom Goodman-Hill, in a private ceremony in London after a 1-month engagement. The bride wore a vintage ivory wedding dress and had her brunette hair in a braid. Among the guests were David Walliams, Martin Freeman, Amanda Abbington and Lauren Crace.
- She was accepted into the Royal Academy of Dramatic Art in 2008.
- Was five months pregnant when she completed filming on Baptiste (2019).
- Gave birth to her first child at age 36, a son, in February 2019. Child's father is her husband, Tom Goodman-Hill.
- Jessica Raine and her husband, Tom Goodman-Hill both worked on the UK series Call the Midwife. Jessica Raine was the central character on the series for the first three seasons and Tom Goodman-Hill had a guest spot in season one, episode four, where he played the husband of a woman with toxemia. While Tom Goodman-Hill's story in the series focused on midwife Cynthia (Now Sister Mary-Cynthia), the two would have met.
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