Sister Duos in Series

Tatyana Ali and Karyn Parsons in The Fresh Prince of Bel-Air (1990)

Marianly Tejada and Melissa Collazo in One of Us Is Dancing! (2021)

Maisie Williams and Sophie Turner in Game of Thrones (2011)

Troian Bellisario and Torrey DeVitto in Pretty Little Liars (2010)

Sarah Michelle Gellar and Michelle Trachtenberg in Buffy the Vampire Slayer (1997)

Chyler Leigh and Ellen Pompeo in Grey's Anatomy (2005)

Anna Gunn and Betsy Brandt in Breaking Bad (2008)

Katie Cassidy and Caity Lotz in Arrow (2012)

Kristin Kreuk and Nicole Gale Anderson in Beauty and the Beast (2012)

Sarah Hyland and Ariel Winter in Modern Family (2009)

Roseanne Barr and Laurie Metcalf in Roseanne (1988)

Tamera Mowry-Housley and Tia Mowry in Sister, Sister (1994)

Claire Danes, Amy Hargreaves, and James Rebhorn in Homeland (2011)

Lana Parrilla and Rebecca Mader in Once Upon a Time (2011)

Lauren Cohan and Emily Kinney in The Walking Dead (2010)

Angel Theory and Lauren Ridloff in The Walking Dead (2010)

Fran Drescher, Nicholle Tom, Benjamin Salisbury, and Madeline Zima in The Nanny (1993)

Brian Keith, Kathy Garver, Anissa Jones, and Johnny Whitaker in Family Affair (1966)

Imogen Clawson and Rachel Shenton in All Creatures Great & Small (2020)

Claire Foy and Vanessa Kirby in The Crown (2016)

Elisha Cuthbert and Eliza Coupe in Happy Endings (2011)

Evi Daelli and Ioanna Pilihou in Eftyhismenoi mazi (2007)

Candace Cameron Bure and Jodie Sweetin in Full House (1987)

Caroline Rhea and Beth Broderick in Sabrina the Teenage Witch (1996)

Gina Rodriguez and Yael Grobglas in Jane the Virgin (2014)

Calista Flockhart, Rachel Griffiths, and Dave Annable in Brothers & Sisters (2006)

Reba McEntire and Belissa Escobedo in Happy's Place (2024)

Julia Ragnarsson and Dilan Gwyn in Two Sisters (2021)

Liv and Maddie (2013)

Blake Lively and Leighton Meester in Gossip Girl (2007)

Katherine Heigl and Sarah Chalke in Firefly Lane (2021)

Melanie Scrofano and Dominique Provost-Chalkley in Wynonna Earp (2016)

Brittany Daniel and Cynthia Daniel in Sweet Valley High (1994)

Jessica Biel and Elizabeth Banks in The Better Sister (2025)

Carmela Zumbado and Jenna Ortega in You (2018)