Brother Duos in Series

Jensen Ackles and Jared Padalecki in Supernatural (2005)

Wentworth Miller and Dominic Purcell in Prison Break (2005)

Nikolaj Coster-Waldau and Peter Dinklage in Game of Thrones (2011)

Tanner Buchanan, Xolo Maridueña, Dallas Dupree Young, and Okea Eme-Akwari in Peacetime in the Valley (2024)

Charlie Heaton and Noah Schnapp in Stranger Things (2016)

Tara Sands and Eric Stuart in Yu-Gi-Oh! (2000)

Mark Gatiss and Benedict Cumberbatch in Sherlock (2010)

Ian Somerhalder and Paul Wesley in The Vampire Diaries (2009)

Jason Lee and Ethan Suplee in My Name Is Earl (2005)

Charlie Sheen and Jon Cryer in Two and a Half Men (2003)

Norman Reedus and Michael Rooker in The Walking Dead (2010)

Travis Fimmel and Clive Standen in Vikings (2013)

Neil Hopkins and Dominic Monaghan in Lost (2004)

Daniel Gillies and Joseph Morgan in The Originals (2013)

Cillian Murphy and Paul Anderson in Peaky Blinders (2013)

"Simon & Simon" Jameson Parker, Gerald McRaney 1981 CBS

Michael McKean and Bob Odenkirk in Better Call Saul (2015)

Nicholas Alexander Chavez and Cooper Koch in Monster (2022)

Rainn Wilson and Michael Schur in The Office (2005)

Pedro Alonso and Álvaro Morte in La boda de Berlín (2020)

Giannis Bezos and Dimitris Mavropoulos in Eftyhismenoi mazi (2007)

Pedro Pascal and Gabriel Luna in Kin (2023)

Paddy Considine and Matt Smith in House of the Dragon (2022)

Samuel West and Callum Woodhouse in All Creatures Great & Small (2020)

Kelsey Grammer and David Hyde Pierce in Frasier (1993)

Michael Landon and Dan Blocker in Bonanza (1959)

James Lafferty and Chad Michael Murray in One Tree Hill (2003)

Steve Buscemi and Shea Whigham in Boardwalk Empire (2010)

Adrian Pasdar and Milo Ventimiglia in Heroes (2006)

Paulo Costanzo and Mark Feuerstein in Royal Pains (2009)

Kevin Dillon and Adrian Grenier in Entourage (2004)

Joey Lawrence, Andrew Lawrence, and Matthew Lawrence in Brotherly Love (1995)

Gary Lewis and Graham McTavish in Outlander (2014)

Paul Gorman in Outlander (2014)

David Oakes and Tom Hughes in Victoria (2016)