- Is one of the few cast members of Lost (2004) who did not have to audition, because his former collaborator (from Alias: Codinome Perigo (2001)) J.J. Abrams thought of O'Quinn for the part of Locke before the actor was even offered it.
- Actually learned how to properly throw and handle knives for his role on Lost (2004).
- He is one of eleven children.
- Not many know that he is a talented guitarist and singer. He is a particularly big fan of Neil Young and can apparently do a dead-on impression of him.
- Although always friendly onset, he keeps private and mysterious habits apart from his younger Lost (2004) co-stars, who often get together for wild parties when not shooting. He keeps this enigmatic aura so they will regard him similarly to the way they regard his mysterious character Locke.
- Has been balding since his early 20s and has appeared with a partially or entirely shaved head in most of his films.
- Has had roles in both of J.J. Abrams's hit television series Alias: Codinome Perigo (2001) and Lost (2004).
- He elongated his last name to "O'Quinn" from his real name of "Quinn" to distinguish himself from another person named Terry Quinn already acting in films.
- In an episode of Lost (2004), his character Locke's parents were played by Kevin Tighe and Swoosie Kurtz, who are both only eight years O'Quinn's senior.
- Is good friends with 1013 Productions' Chris Carter, having appeared in most of his work: as a guest star in two episodes of Arquivo X (1993), a supporting role in Arquivo X: O Filme (1998) and recurring roles on Harsh Realm (1999) and Millennium (1996).
- Has an Irish Terrier named Reggie.
- Attended and graduated from the University of Iowa in Iowa City, Iowa.
- Has been experienced in percussion since high school.
- Grew up in Newberry, Michigan and was raised Roman Catholic.
- Attended and graduated from Central Michigan University in Mount Pleasant, Michigan.
- Has two sons: Oliver Quinn (b. 1984) and Hunter Quinn (b. 1986).
- Has English and Irish ancestry.
- His brother Thomas Anthony Quinn is also an actor, who acts and teaches theatre in central Illinois.
- Has appeared in episodes of two different series with the same name. Both Millennium (1996) and Lost (2004) have had episodes featuring O'Quinn called "Walkabout".
- Although he played Chris Nash's father in A Primeira Transa de Jonathan (1985), he is only nine years his senior in real life.
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