- Was offered the chance to direct Star Wars: Episódio VI - O Retorno de Jedi (1983) but he declined.
- Turned down the chance to direct RoboCop: O Policial do Futuro (1987).
- Costumes in his films are usually designed by his sister Denise Cronenberg.
- Turned down the chance to direct Top Gun: Ases Indomáveis (1986).
- Has admired bugs and insects since childhood. This fascination has lingered on, and can be felt through many of his films.
- Deferred his own salary to make Spider - Desafie Sua Mente (2002).
- He once said that Scanners: Sua Mente Pode Destruir (1981) was the most frustrating directing job he'd ever had.
- Was set to direct O Vingador do Futuro (1990). He even wrote a few drafts of the script before Paul Verhoeven took over.
- Upon meeting Cronenberg in the 1980's, Martin Scorsese confessed to admiring the director's work but having been scared to meet him as a result of it. Cronenberg replied, "You made Taxi Driver and you were afraid to meet me?".
- John Carpenter paid homage to him in Fuga de Nova York (1981). One of the United States Police Force guards is on the line with Hauk, then adds that Cronenberg is on the line for him. Another person paid homage to in the movie was George A. Romero, who had Isaac Hayes's right-hand man named after him.
- His regular cinematographer until 1988 was Mark Irwin until Gêmeos - Mórbida Semelhança (1988), on which Irwin was unable to work because of his commitment to A Bolha Assassina (1988). Cronenberg then hired Peter Suschitzky, who became his regular cinematographer, and Cronenberg and Irwin have not worked together since then.
- His father was born in Baltimore, Maryland, and his mother was born in Toronto, Ontario, Canada. All of his grandparents were Lithuanian Jewish immigrants. His father, who died at age 61, was a bookstore owner and sometime columnist for The Toronto Telegram ( 1876 - 1971 ). His mother was a piano rehearsal accompanist for the Canadian National Ballet.
- Has directed 2 actors to Oscar nominations: William Hurt (Best Supporting Actor, Marcas da Violência (2005)) and Viggo Mortensen (Best Actor, Senhores do Crime (2007)).
- Has often referred to Os Filhos do Medo (1979) as his own twisted version of Kramer vs. Kramer (1979).
- President of the 'Official Competition' jury at the 52nd Cannes International Film Festival in 1999.
- His crew referred to the final Brundlefly monster seen in the climax of A Mosca (1986) as the Space Bug.
- Directed an episode of Loja do Terror (1987), The Services, called Faith Healer. 13 years later, he appeared in the Friday the 13th film (unreleated to the series), Jason X (2001).
- Cites Winter Kept Us Warm (1965) as his inspiration for becoming a filmmaker. It was screened at the University of Toronto when he was a student.
- Inducted to Canada's Walk of Fame in 1999.
- His father was a journalist and his mother played the piano. These roles are reversed in A Mosca (1986), in which Jeff Goldblum plays the piano to impress Geena Davis, who plays a journalist.
- At one point he was in line to direct Crime de um Detetive (2003), with Al Pacino in the lead.
- Golden Lion for Lifetime Achievement at the 75th Venice International Film Festival in 2018.
- Although he has done most of his filmmaking in the Canadian film industry, since Enraivecida na Fúria do Sexo (1977) he has cast non-Canadians in the top billed roles of his films.
- Father of Caitlin Cronenberg, Brandon Cronenberg, and Cassandra Cronenberg. Brother of costume designer Denise Cronenberg. Uncle of Aaron Woodley.
- He spent about a year in 1971 in the small medieval village Tourrettes-sur-Loup, France, possibly in the commune, trying to become a novelist.
- He was awarded the 2002 Queen Elizabeth II's Golden Jubilee Medal from the Canadian Governor General. He lives in Toronto, Ontario, Canada.
- President of the jury at the 18th Neuchâtel International Fantastic Film Festival (NIFFF), which took place in Switzerland from July 6-14, 2018.
- He was awarded the 2012 Queen Elizabeth II's Diamond Jubilee Medal from the Canadian Governor General. He lives in Toronto, Ontario, Canada.
- Profiled in "American Classic Screen Interviews" (Scarecrow Press). (2010)
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