- While filming the scene in Conta Comigo (1986) in which Gordie and Vern are being chased by a train, he couldn't get Wil Wheaton and Jerry O'Connell to look frightened enough, so after a take, he proceeded to yell at them until they began to cry. He then filmed the scene over again.
- Was best friends in high school with Richard Dreyfuss, whom he later directed in Conta Comigo (1986).
- Of all the films he has directed, he considers Conta Comigo (1986) as his masterpiece and his favorite film.
- Named his production company "Castle Rock" after a fictional town created by Stephen King (the two have worked as a team on several movies together).
- Growing up, he lived right across from future wife Penny Marshall's home in the Bronx.
- Wore a toupee in Tudo em Família (1971).
- Directed three actors in Oscar-nominated performances: Kathy Bates, Jack Nicholson, and James Woods. Bates won for her performance in Louca Obsessão (1990).
- Directed three of the movies ranked in American Film Institute's list of top 100 U.S. love stories in 2002: Harry e Sally: Feitos um para o Outro (1989), ranked #25; Meu Querido Presidente (1995), ranked #75, and A Princesa Prometida (1987), ranked #88.
- Co-wrote the first episode of Happy Days (1974).
- Best friends with Billy Crystal.
- Despite their antagonistic roles on Tudo em Família (1971) as Meathead and Archie, Reiner grew quite close to actor Carroll O'Connor off-camera.
- Received a star on the Hollywood Walk of Fame; it is next to his father's star. (outubro de 1999)
- Son of Estelle Reiner and Carl Reiner.
- Was good friends with Robin Williams, and revealed as he grieved over his passing away from suicide that, like Williams, he has suffered from depression.
- He has three children with wife Michele Reiner.
- He is of Ashkenazi Jewish descent (from Austria and Romania on his father's side, and Germany, Russia, and Poland on his mother's side).
- His acting mentor is the late Carroll O'Connor.
- Brother of painter Lucas Reiner and poet/playwright/author Sylivia Ann Reiner.
- In his first project following Tudo em Família (1971), he produced, co-wrote, and co-starred with then-wife Penny Marshall in the TV movie Mais do que Amigos (1978), a romantic comedy based on the couple's own courtship.
- Is portrayed by Trey Parker in the South Park (1997) episode "Butt Out" (Season 7, Episode 13).
- Reiner spearheaded a ballot initiative in California to add a tax on cigarettes to pay for early childhood development programs. It passed by a narrow margin. (1998)
- He graduated from Beverly Hills High School in 1964. Other famous alumni include Angelina Jolie, Michael Klesic, Nicolas Cage, Lenny Kravitz, David Schwimmer, Jonathan Silverman, Gina Gershon, Rhonda Fleming, Jackie Cooper, Antonio Sabato Jr., Pauly Shore, Michael Tolkin, Betty White, Corbin Bernsen, Elizabeth Daily, Albert Brooks, and Crispin Glover.
- Named It's a Wonderful Life as his favorite film in an AFI poll.
- He has directed three films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Isto é Spinal Tap (1984), A Princesa Prometida (1987), and Harry e Sally: Feitos um para o Outro (1989).
- Replaced Ted Griffin as the director of Dizem por Aí... (2005) 12 days into principal photography.
- He is one of only two directors to have a film on both Roger Ebert's "Great Movies" list and "Most Hated" list, with Isto é Spinal Tap (1984) being on the former and O Anjo da Guarda (1994) being on the latter. The other director is Bob Clark.
- Friends with Bea Arthur and Michael Douglas.
- His favorite sports movie of all time is Desafio à Corrupção (1961).
- Auditioned for and took his role on Tudo em Família (1971), not expecting the show to last long, believing the series would not catch on with a wide audience of viewers. At the time, Reiner was only seeking temporary or part-time acting work, as his long-term ambitions were in writing and directing.
- Adoptive father of Tracy Reiner, Penny Marshall's daughter from a previous marriage.
- Best known by the public for his role as Michael "Meathead" Stivic on Tudo em Família (1971).
- Ex-brother-in-law of Garry Marshall and Ronny Hallin.
- Rob and wife Michele Reiner are the parents of screenwriter Nick Reiner, Jake Reiner, and Romy Reiner.
- Casting agents Jane Jenkins and Janet Hirshenson have cast most of Rob's films starting with Garota Sinal Verde (1985).
- Is a big fan of The Beach Boys.
- He has directed one film that has been nominated for the Best Picture Oscar: Questão de Honra (1992). He has also appeared in one Best Picture nominee: O Lobo de Wall Street (2013).
- Former comedic partner of Larry Bishop.
- Ex-son-in-law of Anthony W. Marshall and Marjorie Marshall.
- His father Carl Reiner had met Carroll O'Connor when O'Connor first met the young, unfamiliar actor, who was living at the house where Reiner's father, was at the time, director of Dick Van Dyke Show (1961) along with Reiner's mother, Estelle Reiner, and was attending the University of California-Los Angeles, with a major in Drama.
- Supported Al Gore during the 2000 presidential election.
- Born on exactly the same date as Martin Kove (of Karate Kid fame).
- Brother-in-law of Maud Winchester.
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