Charles Krauthammer nasceu o 13 de março de 1950 em Nova Iorque, Nova Iorque, EUA. Foi casado com Robyn Trethewey. Morreu o 21 de junho de 2018 em Atlanta, Geórgia, EUA.
When he was a medical student, had a diving accident, in Massachusetts in July 1972, which injured his spinal cord and left him paralyzed. Later regained the use of the upper part of his body.