Bob Saget and Dave Coulier became friends through the L.A. Comedy circuit. Coulier lived on Saget's couch in his early days as a comedian, similar to struggling comedian Joey Gladstone residing in the basement of Danny Tanner's house.
Mary-Kate Olsen is left-handed and Ashley Olsen is right-handed. That is why, throughout the show, Michelle uses both of her hands to write and eat.
The mother of the girl, Pam, who was Danny's wife, was killed by a drunk driver in a car accident, as revealed in one episode.
Bob Saget considered leaving the show after the first season due to his disapproval of the writing and story lines.
Sensing some awkwardness among themselves, Bob Saget, John Stamos, and Dave Coulier took a road trip to Las Vegas after the first season concluded in order to develop their chemistry, particularly focusing on Stamos, since Saget and Coulier were already friends prior to the show. During the trip, Stamos and Coulier, both single at the time, bonded and even went on double dates together, while Saget, who was married at the time, stayed behind. As a result, Stamos and Coulier became good friends, which the writers decided to incorporate into future seasons. They began working together in various contexts, first in advertising and later on a radio evening show, and shared many more scenes together on the show.