During the series, whenever Denny Crane (William Shatner) opens his cell phone, it makes the same sound effect as the communicators from the original "Star Trek" series in which he played the role of Captain James T. Kirk.
The ringtone of Catherine Piper (Betty White) is the opening theme of David E. Kelly's other show "The Practice" (1997), from which this show is spun off.
James Spader (Alan Shore) and William Shatner (Denny Crane) are the only cast members to appear in every episode of the series.
Nearly all episodes (except season two, episode twenty-six, "Spring Fever," and several others in the first season) end with Denny and Alan sitting on the balcony, having a drink, smoking a cigar, and discussing the events of the episode.
David E. Kelley gave away the rights to the American adaptation of "Life on Mars" (2006), after making a failed pilot, in exchange for a final season of this show, with the minimum of episodes necessary for this show to achieve syndication.