This was the least financially successful entry in the "Scary Movie" series.
Lindsay Lohan refused to kiss Charlie Sheen during filming due to his somewhat erratic behavior. A body double was used instead.
Anna Faris did not return for Scary Movie 5 (2013) due to her pregnancy. Other cast members from the previous films, such as Regina Hall, Kevin Hart and Anthony Anderson, were offered roles but opted not to return.
This was the only film in the entire "Scary Movie" franchise that did not feature any main characters from the first 4 films, i.e., Cindy Campbell (Anna Faris) and Brenda Meeks (Regina Hall). In a podcast, Anna Faris said that she was "too old" to return and Regina Hall became "expensive." Initially in 2009, The Weinstein Company decided this was going to be a reboot, which meant there would be no returning characters.
Marlon Wayans, who originally created the "Scary Movie" franchise alongside his brothers Keenen Ivory Wayans and Shawn Wayans back in 2000, said in an interview that the studio asked the Wayans Brothers to return for Scary Movie 5 (2013), but the brothers declined. Marlon Wayans later released his own horror movie spoof, Inatividade Paranormal (2013), which performed so well at the box office that it spawned a sequel, with Inatividade Paranormal 2 (2014) released the following year.