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Follows a team of Naval Criminal Investigative Service (NCIS) Special Agents who investigate criminal cases involving military personnel in New Orleans, Louisiana aka The Big Easy, a city known for its music, entertainment, and decadence.

NCIS: New Orleans is a drama about the local field office that investigates criminal cases involving military personnel in The Big Easy, a city known for its music, entertainment, and decadence. Leading the team is Special Agent Dwayne Pride, a.k.a. "King," a native of New Orleans who is driven by his need to do what is right. Working with Pride is his longtime friend and colleague Special Agent Christopher Lasalle, who plays hard but works harder; tough and acerbic Special Agent Tammy Gregorio, a former FBI Agent who was sent to New Orleans to investigate NCIS and upon completion joined Pride's team, Forensic Agent Sebastian Lund, a brilliant scientist who left the lab and, after much training, became an agent; and Special Agent Hannah Khoury, a seasoned agent who specializes in international counter-intelligence and has spent most of her career on overseas assignments. Supporting them is coroner Dr. Loretta Wade, who is as eccentric as she is smart, and Investigative Computer Specialist Patton Plame, an animated and talented hacker. This colorful city that harbors a dark side is a magnet for service personnel on leave, and when overindulgence is followed by trouble, Pride's team is at its best.

The adventures and missions of a defence doing everything that they can to protect the country and the world from all kinds of attacks and threats. All of the team members rely on each other to defeat all enemies and make sure that everyone lives in peace.—RECB3