Was one of the first Amazon Studios pilots.
Several of the actors featured on the show are actually stand up comics from the Denver area, many of whom have worked closely with the Grawlix before their breakout into television. Chris Charpentier (The Referee), David Gborie (Zack the Lawbro), Adrian Mesa (The Janitor), and Jordan Doll (Jerry) are all comics who got their start alongside Ben Roy, Andrew Orvedahl, and Adam Cayton-Holland; the creators of Those Who Can't.
Was renewed for a 13 episode long second season before the first had aired.
Those Who Can't was first created as a pilot for Amazon Prime before being picked up by TruTV.
The Lions Lair (a bar featured in the show) is a real bar on Colfax avenue in Denver. Adam, Ben, and Andrew hosted a weekly stand up comedy open mic there for years before creating Those Who Can't.