Billie Fairchild, who plays Grandma in the film, is actually suffering from Alzheimer's Disease, so she was not entirely aware she was acting in a film, although director Trey Edward Shults said she had a wonderful time at the "Thanksgiving."
The title character is actually based on director Trey Edward Shults's cousin and Krisha Fairchild's niece Nica, a longtime addict who relapsed at a family reunion and died of an overdose soon after.
Krisha is seen with a missing portion of her finger, which is never explained throughout the film; in real-life actress Krisha Fairchild lost the tip of her index finger while trying to break up a dogfight shortly before the start of filming. She wanted to back out of the film because of the injury but eventually agreed to stay on.
Filmed in nine days.